It is interesting, i have built a couple Distortion+s, and a couple of the DOD 250s(literally like 99% the same, but with different clippers(i prefer the 250 sound to the D+ actually )) but i never quite got along with any of them.
In my case, i think it is pretty much the same story as another pedal i don't really like, and that i actually feel has a similar sonic character, the Boss DS1. That story being, that i think i just don't have the right amp to make the things not sound like shit. Because a lot of people have made them sound a lot better than what i wound up with. Bob Mould being one excellent example, his classic Sugar/Husker Du sound being a D+ into a very loud Marshall.
It seems that everyone who really loves them, pretty much uses them to boost Marshalls. For my Vox- and Fender-like amps the sound was harsh, thin, unnatural, and kind of had a boxy sort of yuck distortion. I suspect that it is simply about the brightness of the amps i like, overly accentuating the simple sharp clipping of the pedlols in question. Some day, i will have to try them into a proper big marshall i think, in order to finally "get it".